FEBS Lett 579:31193125 Mihm MJ, Bauer JA (2002) Peroxynitrite-induced inhibition and nitration of cardiac myofibrillar creatine kinase
Khajuria A and Houston DS (2000)
Your doctor will conduct a comprehensive clinical assessment including: Detailed medication and supplement history , including over-the-counter vitamins and injections Review of symptoms suggesting liver, kidney, or haematological disease Physical examination for hepatomegaly, splenomegaly, jaundice, or lymphadenopathy Additional blood tests , such as full blood count, liver function tests, renal function, and inflammatory markers Depending on initial findings, further investigations may include: Liver ultrasound or imaging if hepatic pathology is suspected Haematology referral for blood film examination, bone marrow biopsy, or specific tests for myeloproliferative disorders Measurement of holotranscobalamin or methylmalonic acid if functional B12 status needs clarification despite high total B12 Targeted investigations based on clinical findings and following NICE guidance for suspected serious conditions Treatment focuses on addressing the underlying cause rather than the elevated B12 itself
Chemotherapy activates the DDR pathway
The presence of K48 linkage was confirmed by reaction with OTUB1 (5 M), a K48-linkagespecific DUB
